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mepartricin
Sign in to saveAlso known as mepartricin A
Mepartricin is a macrolide polyene compound that is useful for urethra, prostate, and bladder function. It has been studied for use in treating chronic pelvic pain syndrome and benign prostatic hyperplasia.
Chemical data
- Formula
- C60H88N2O19
- Molecular weight
- 1141.3 g/mol
- IUPAC name
- methyl (19E,21E,23Z,25Z,27E,29E,31E)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,7,9,13,37-heptahydroxy-17-[5-hydroxy-7-[4-(methylamino)phenyl]-7-oxoheptan-2-yl]-18-methyl-11,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate
- SMILES
- C[C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)OC\2CC3C(C(CC(O3)(CC(CC(CC(CC(CC(=O)CC(CC(=O)OC(C(/C=C/C=C/C=C\C=C/C=C/C=C/C=C2)C)C(C)CCC(CC(=O)C4=CC=C(C=C4)NC)O)O)O)O)O)O)O)O)C(=O)OC)O)N)O
- InChIKey
- GVEVTKSEPQUIJA-PLDHRHJXSA-N
- XLogP
- 3.6
- Polar surface area
- 355 Ų
- H-bond donors
- 12
- H-bond acceptors
- 21
- Formal charge
- 0
via PubChem
Research
108 papers- Mepartricin long-term administration regulates steroid hormone and adrenergic receptor concentrations in the prostate of aged rats.Journal of veterinary pharmacology and therapeutics · 2006
- Effect of mobile phase pH on liquid chromatography retention of mepartricin related compounds and impurities as support to the structural investigation by liquid chromatography-mass spectrometry.Journal of pharmaceutical and biomedical analysis · 2022
- Estrogen suppression as a pharmacotherapeutic strategy in the medical treatment of benign prostatic hyperplasia: evidence for its efficacy from studies with mepartricin.Wiener klinische Wochenschrift · 1998
- The structure of mepartricin A and mepartricin B.The Journal of antibiotics · 1980
- [Mepartricin as medical treatment of benign prostatic hypertrophy].Journal d'urologie · 1993
via PubMed
Wikidata facts
- Mass
- 1140.598129
Show 3 more facts
- chemical formula
- C₆₀H₈₈N₂O₁₉
- isomeric SMILES
- C[C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)OC\2CC3C(C(CC(O3)(CC(CC(CC(CC(CC(=O)CC(CC(=O)OC(C(/C=C/C=C/C=C\C=C/C=C/C=C/C=C2)C)C(C)CCC(CC(=O)C4=CC=C(C=C4)NC)O)O)O)O)O)O)O)O)C(=O)OC)O)N)O
- canonical SMILES
- CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(CC(CC(CC(=O)CC(CC(=O)OC1C(C)CCC(CC(=O)C3=CC=C(C=C3)NC)O)O)O)O)O)O)O)O)C(=O)OC)OC4C(C(C(C(O4)C)O)N)O
Sources (1)
via Wikidata · CC0
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Encyclopedic overview
2 sectionsContents
- Pharmacodynamics
- References
Mepartricin is a macrolide polyene compound that is useful for urethra, prostate, and bladder function. It has been studied for use in treating chronic pelvic pain syndrome and benign prostatic hyperplasia.
==Pharmacodynamics==
Excerpted from Wikipedia’s “mepartricin” article, available under the CC BY-SA 4.0 licence.
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