Structure via PubChem · Public domain (PubChem)
terazosin
Sign in to saveAlso known as ABBOTT-45975, Hytrin®, Terazosine, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine, Térazosine, Terazosina, Terazosinum
Chemical data
- Formula
- C19H25N5O4
- Molecular weight
- 387.4 g/mol
- IUPAC name
- [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
- SMILES
- COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
- InChIKey
- VCKUSRYTPJJLNI-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 103 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1987
- Admin. routes
- oral
- Indications
- benign prostatic hyperplasia, internal carotid artery stenosis, hypertension, atherosclerosis
via ChEMBL · EBI
Research
1,055 papers- Terazosin.2006
- Terazosin for benign prostatic hyperplasia.The Cochrane database of systematic reviews · 2002
- [Terazosin].Deutsche medizinische Wochenschrift (1946) · 1998
- Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence.European journal of pharmacology · 2024
- Terazosin in the treatment of benign prostatic hyperplasia: the United States experience.British journal of urology · 1992
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 387.191
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₉H₂₅N₅O₄
- medical condition treated
- arterial hypertension
- canonical SMILES
- COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
- World Health Organisation international non-proprietary name
- terazosin
- defined daily dose
- 5
- Commons category
- Terazosin
- significant drug interaction
- levobunolol
Sources (8)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- Research on neuroprotective effects
- References
Terazosin, sold under the brand name Hytrin among others, is a medication used to treat symptoms of an enlarged prostate and high blood pressure. For high blood pressure, it is a less preferred option. It is taken by mouth.
Common side effects include dizziness, headache, feeling tired, swelling, nausea, and low blood pressure with standing. Severe side effects may include priapism and low blood pressure. Prostate cancer should be ruled out before starting treatment. It is an alpha-1 blocker and works by relaxing blood vessels and the opening of the bladder.
Excerpted from Wikipedia’s “terazosin” article, available under the CC BY-SA 4.0 licence.