Structure via PubChem · Public domain (PubChem)
met-enkephalin
Sign in to saveAlso known as POMC(237-241), L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionine, YGGFM
Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.
In the Vinony graph
Within Vinony's link graph, met-enkephalin is referenced by 778 other articles, and connects out to peptide, metabolism and orexin.
Vinony files it under Chembox image size set, Chemical articles with multiple compound IDs and Delta-opioid receptor agonists.
Its subject is documented across 7 Wikipedia language editions.
Chemical data
- Formula
- C27H35N5O7S
- Molecular weight
- 573.7 g/mol
- IUPAC name
- (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
via PubChem
Drug data · ChEMBL
- Molecule type
- Protein
via ChEMBL · EBI
Research
6,988 papers- Endocrine control of hypothalamic and pituitary met-enkephalin and beta-endorphin contents.Neuroendocrinology · 1991
- Immunofluorescence with Met-enkephalin and Leu-enkephalin antibodies in the guinea pig cochlea.Hearing research · 1984
- [Methionine-enkephalin (Met-Enk) and leucine-enkephalin (Leu-Enk)].Nihon rinsho. Japanese journal of clinical medicine · 2005
- Immunocytochemical distribution of Met-enkephalin-Arg6-Gly7-Leu8 (Met-8) in the auditory system of the rat.Hearing research · 2004
- Met-enkephalin immunoreactivity in blood platelets.Life sciences · 1982
via PubMed
Wikidata facts
- Subclass of
- enkephalin
- Part of
- proopiomelanocortin
- Mass
- 573.22571946
Show 6 more facts
- chemical formula
- C₂₇H₃₅N₅O₇S
- isomeric SMILES
- CSCC[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N
- found in taxon
- Mytilus edulis
- Commons category
- Met-enkephalin
- canonical SMILES
- CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)O
Sources (3)
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- History
- Chemistry
- Biochemistry
- Distribution
- Biosynthesis
- Clearance
- Biological activity
- Pharmacokinetics
- See also
- References
Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.
== History == Met-enkephalin was discovered and characterized by John Hughes, Hans Kosterlitz, et al. in 1975 after a search for endogenous ligands of the opioid receptors.
Excerpted from Wikipedia’s “met-enkephalin” article, available under the CC BY-SA 4.0 licence.