mitragynine
Sign in to saveMitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. It has also been researched for its use to potentially manage symptoms of opioid withdrawal. It is a partial agonist of the mu-opioid receptors; and as such can produce effects similar to those of classical opioids such as morphine.
Key facts
- Drug.bioavailability
- 21%
- Drug.drug_name
- Mitragynine
- Drug.image
- Mitragynine v2.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Mitragynine molecule ball.png
- Drug.image_class2
- bg-transparent
- Drug.legal_AU
- S8
- Drug.legal_BR
- B1
- Drug.legal_CA
- Unscheduled
- Drug.legal_DE
- NPSG
- Drug.legal_NZ
- Unscheduled
- Drug.legal_UK
- PSA
- Drug.legal_US
- unscheduled
- Drug.legal_UN
- unscheduled
- Drug.legal_status
- In general legal for medical and research uses as a research chemical.
- Drug.routes_of_administration
- By mouth
- Drug.IUPAC_name
- methyl (16E)-9,17-dimethoxy-16,17-didehydro-20β-corynan-16-carboxylate
- Drug.metabolites
- 7-Hydroxymitragynine
via Wikipedia infobox
Wikidata facts
- Mass
- 398.221
Show 4 more facts
- chemical formula
- C₂₃H₃₀N₂O₄
- canonical SMILES
- CCC1CN2CCC3=C(C2CC1C(=COC)C(=O)OC)NC4=C3C(=CC=C4)OC
- isomeric SMILES
- CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC
- Commons category
- Mitragynine
Sources (2)
via Wikidata · CC0
~13 min read
Article
24 sectionsContents
- Uses
- Medical
- Pain
- Chronic pain
- Opioid withdrawal
- Recreational
- Adverse effects
- Dependence and withdrawal
- Chemistry
- Solubility
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Metabolism
- Phase I
- Phase II
- History
- Society and culture
- Legal status in the United States
- Research
- Research limitations
- Toxicology
- See also
- References
Mitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. It has also been researched for its use to potentially manage symptoms of opioid withdrawal. It is a partial agonist of the mu-opioid receptors; and as such can produce effects similar to those of classical opioids such as morphine.
Mitragynine is the most abundant active alkaloid in kratom. In Thai varieties of kratom, mitragynine is the most abundant component (up to 66% of total alkaloids), while 7-hydroxymitragynine (7-OH) is a minor constituent (up to 2% of total alkaloid content). In Malaysian kratom varieties, mitragynine is present at lower concentration (12% of total alkaloids). Total alkaloid concentration in dried leaves ranges from 0.5 to 1.5%. Such preparations are orally consumed and typically involve dried kratom leaves which are brewed into tea or ground and placed into capsules.