Structure via PubChem · Public domain (PubChem)
mobocertinib
Sign in to saveAlso known as TAK-788, TAK788
Mobocertinib, sold under the brand name Exkivity, is used for the treatment of non-small cell lung cancer.
In the Vinony graph
Within Vinony's link graph, mobocertinib is referenced by 217 other articles, and connects out to public domain, digital object identifier and leukemia.
It is catalogued under topics including Amides, Chemical articles with multiple CAS registry numbers and Chemicals using indexlabels.
Its subject is documented across 4 Wikipedia language editions.
Chemical data
- Formula
- C32H39N7O4
- Molecular weight
- 585.7 g/mol
- IUPAC name
- propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate
- SMILES
- CC(C)OC(=O)C1=CN=C(N=C1C2=CN(C3=CC=CC=C32)C)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
- InChIKey
- AZSRSNUQCUDCGG-UHFFFAOYSA-N
- XLogP
- 4.4
- Polar surface area
- 114 Ų
- H-bond donors
- 2
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2021
- Admin. routes
- oral
- Indications
- liver disease, non-small cell lung carcinoma, kidney disease, neoplasm
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 585.3063527280002
- Has use
- medication
Show 7 more facts
- canonical SMILES
- CC(C)OC(=O)C1=CN=C(N=C1C2=CN(C3=CC=CC=C32)C)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
- chemical formula
- C₃₂H₃₉N₇O₄
- physically interacts with
- epidermal growth factor receptor
- Commons category
- Mobocertinib
- legal status (medicine)
- boxed warning
- subject has role
- protein kinase inhibitors
- medical condition treated
- non-small-cell lung carcinoma
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Mechanism of action
- Pharmacokinetics
- Warnings
- Adverse effects
- History
- References
- External links
{{Infobox drug | image = Mobocertinib.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = Exkivity | Drugs.com = | MedlinePlus = | DailyMedID = Mobocertinib | pregnancy_AU = D | pregnancy_AU_comment = | pregnancy_category= Contraindicated | routes_of_administration = By mouth | class = Antineoplastic | ATC_prefix = L01 | ATC_suffix = EB10 | ATC_supplemental =
Excerpted from Wikipedia’s “mobocertinib” article, available under the CC BY-SA 4.0 licence.