MTDH
Sign in to saveAlso known as 3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3, metadherin
Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.
Gene data
MTDH- Name
- metadherin
- Type
- protein-coding
- Position
- 97,643,612–97,730,260 (+)
- Aliases
- 3D3, AEG-1, AEG1, LYRIC, LYRIC/3D3
- Ensembl
- ENSG00000147649
- RefSeq RNA
- NM_001363136.1, NM_001363137.1, NM_001363138.1, NM_001363139.1, NM_178812.4
- RefSeq protein
- NP_001350065.1, NP_001350066.1, NP_001350067.1, NP_001350068.1, NP_848927.2
Enables NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Located in endoplasmic reticulum; nuclear lumen; and perinuclear region of cytoplasm. Implicated in hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
metadherin
- Symbol
- MTDH
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:97,643,612-97,730,260
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 12089
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/92140
- genomic end
- 97730260
- genomic start
- 97644184
- chromosome
- human chromosome 8
- cytogenetic location
- 8q22.1
- expressed in
- decidua
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.
== Function ==
Excerpted from Wikipedia’s “MTDH” article, available under the CC BY-SA 4.0 licence.