N-ethylamphetamine

Etilamfetamine, also known as '''N-ethylamphetamine and formerly sold under the brand names Apetinil and Adiparthrol''', is a stimulant drug of the amphetamine family. It was invented in the early 20th century and was subsequently used as an anorectic or appetite suppressant in the 1950s, but was not as commonly used as other amphetamines such as amphetamine, methamphetamine, and benzphetamine, and was largely discontinued once newer drugs such as phenmetrazine were introduced.

Wikidata facts

Mass: 163.136

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Commons category: N-Ethylamphetamine
chemical formula: C₁₁H₁₇N
canonical SMILES: CCNC(C)CC1=CC=CC=C1
MCN code: 2921.46.40

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10 sections

Contents

Pharmacology
Pharmacodynamics
Monoamine releasing agent
Other actions
Pharmacokinetics
Chemistry
Society and culture
Recreational use
Notes
References

Etilamfetamine, also known as '''N-ethylamphetamine and formerly sold under the brand names Apetinil and Adiparthrol', is a stimulant drug of the amphetamine family. It was invented in the early 20th century and was subsequently used as an anorectic or appetite suppressant in the 1950s, but was not as commonly used as other amphetamines such as amphetamine, methamphetamine, and benzphetamine, and was largely discontinued once newer drugs such as phenmetrazine were introduced.

== Pharmacology == === Pharmacodynamics === ==== Monoamine releasing agent ==== Ethylamphetamine is a potent dopamine releasing agent (DRA) in vitro, with an of 88.5nM. This is about 10-fold lower than the of dextroamphetamine. The values of ethylamphetamine for induction of norepinephrine and serotonin release were not reported. However, the values of its dextrorotatory enantiomer dextroethylamphetamine have been reported and were 44.1nM, 28.8nM, and 333nM for norepinephrine, dopamine, and serotonin, respectively. Hence, dextroethylamphetamine acts as a norepinephrine–dopamine releasing agent (NDRA) with weak effects on serotonin.