norfenfluramine
Sign in to saveAlso known as (RS)-norfenfluramine
Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family and a major active metabolite of the appetite suppressants fenfluramine and benfluorex. The compound is a racemic mixture of two enantiomers with differing activities, dexnorfenfluramine and levonorfenfluramine.
Key facts
- Drug.width
- 250px
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 422837453
- Drug.image
- 3-trifluoromethylamphetamine.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Norfenfluramine molecule ball from xtal.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 225px
- Drug.CAS_number
- 19036-73-8
- Drug.PubChem
- 15897
- Drug.IUPHAR_ligand
- 215
- Drug.ChemSpiderID
- 15108
- Drug.UNII
- CLX07A6ZIY
- Drug.ChEBI
- 125411
- Drug.ChEMBL
- 1979333
- Drug.synonyms
- 3-Trifluoromethylamphetamine; 3-TFMA; Desethylfenfluramine; JP-92
- Drug.IUPAC_name
- 1-[3-(trifluoromethyl)phenyl]propan-2-amine
- Drug.C
- 10
via Wikipedia infobox
Research
271 papers- In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions.Pharmacology research & perspectives · 2022
- In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions.Pharmacology research & perspectives · 2022
- Pharmacokinetics of d- and l-norfenfluramine following their administration as individual enantiomers in rats.Epilepsia · 2024
- Effect of Hepatic Impairment on the Pharmacokinetics of Fenfluramine and Norfenfluramine.Journal of clinical pharmacology · 2024
- Stereoselective Analysis of the Antiseizure Activity of Fenfluramine and Norfenfluramine in Mice: Is l-Norfenfluramine a Better Follow-Up Compound to Racemic-Fenfluramine?International journal of molecular sciences · 2024
via PubMed
Wikidata facts
- Mass
- 203.092184
Show 3 more facts
- Commons category
- Norfenfluramine
- chemical formula
- C₁₀H₁₂F₃N
- canonical SMILES
- CC(CC1=CC(=CC=C1)C(F)(F)F)N
Sources (2)
via Wikidata · CC0
~5 min read
Article
3 sectionsContents
- Pharmacology
- See also
- References
Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family and a major active metabolite of the appetite suppressants fenfluramine and benfluorex. The compound is a racemic mixture of two enantiomers with differing activities, dexnorfenfluramine and levonorfenfluramine.
==Pharmacology== Norfenfluramine acts as a serotonin–norepinephrine releasing agent (SNRA) and as a potent serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonist. Both enantiomers of norfenfluramine are active as monoamine releasing agents, although dexnorfenfluramine is more potent than levonorfenfluramine. Similarly, both enantiomers are active as serotonin 5-HT2 receptor agonists, but dexnorfenfluramine is likewise more potent than levonorfenfluramine.