NCF2

Name

neutrophil cytosolic factor 2

Type

protein-coding

Position

183,554,461–183,593,499 (−)

Aliases

NCF-2, NOXA2, P67-PHOX, P67PHOX

Ensembl

ENSG00000116701

RefSeq RNA

NM_000433.4, NM_001127651.3, NM_001190789.2, NM_001190794.2, NM_001410895.1

RefSeq protein

NP_000424.2, NP_001121123.1, NP_001177718.1, NP_001177723.1, NP_001397824.1

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].

via MyGene.info

Gene · Ensembl

neutrophil cytosolic factor 2

Symbol

NCF2

Biotype

Protein coding

Organism

Homo sapiens

Location

1:183,554,461-183,593,499

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein NCF2 PDB 1e96.png

via Wikidata · CC0