Also known as HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1, nudE neurodevelopment protein 1
Nuclear distribution protein nudE homolog 1 is a protein that in humans is encoded by the NDE1 gene.
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012].
Biological process
Nuclear distribution protein nudE homolog 1 is a protein that in humans is encoded by the NDE1 gene.
== Clinical significance == Mutations in NDE1 can cause severe and often fatal defects in fetal brain development.
via MyGene.info
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).