nialamide
Sign in to saveAlso known as BEIH, N-isonicotinyl hydrazide, N-benzyl-beta-(isonicotinylhydrazino)propionamide, N-benzyl-beta-(isonicotinoylhydrazine)propionamide, 2-[2-(benzylcarbamoyl)ethyl]hydrazide, isonicotinic acid, N-[2-(benzylcarbamyl)ethylamino]isonicotinamide, 2-[2-(benzylcarbamoyl)ethyl]hydrazide isonicotinic acid, 2-(2-(benzylcarbamyl)ethyl)hydrazide isonicotinic acid
Nialamide (Niamid, Niamide, Nuredal, Surgex) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity.
Research
1,644 papers- NIALAMIDE IN CHILDREN.Indian pediatrics · 1964
- [Nialamide in gastroenterology].Revista de la Facultad de Medicina, Universidad Nacional de Colombia · 1961
- Intravenous use of nialamide in depression.Psychosomatics · 1961
- [Pyrexia following nialamide].Dapim refuiim. Folia medica · 1968
- On the role of central nervous system catecholamines and 5-hydroxytryptamine in the nialamide-induced behavioural syndrome.British journal of pharmacology · 1972
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Encyclopedic overview
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Nialamide (Niamid, Niamide, Nuredal, Surgex) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity.
Side effects include agitation and insomnia, less frequently dry mouth, dizziness, blurred vision, and hypomania, and rarely leukopenia and hepatitis. As with other MAOIs, a hypertensive crisis can be triggered by co-ingestion of tyramine. It is metabolized into isoniazid, an anti-tuberculosis agent, and so is contraindicated in patients with tuberculosis. The recommended dosage range is 75 to 200 mg per day, with maintenance doses as low as 12.5 mg every other day.
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