Structure via PubChem · Public domain (PubChem)
nicorandil
Sign in to saveAlso known as Ikorel®, SG-75, N-(2-hydroxyethyl)nicotinamide nitrate, 2-nicotinamidoethyl nitrate, SG 75, 2-Nicotinamidoethyl nitrate, Nicorandilum, N-(2-Hydroxyethyl)nicotinamide nitrate
Nicorandil is a vasodilator drug used to treat angina, which is chest pain that results from episodes of transient myocardial ischemia. Angina can be caused by diseases such as atherosclerosis, coronary artery disease, and aortic stenosis.
In the Vinony graph
Vinony's link graph records 432 inbound references to nicorandil, and connects out to valproic acid, voltage-gated calcium channel complex and pentaerythritol tetranitrate.
It sits within the topics 3-Pyridyl compounds, Antianginals and Drugboxes which contain changes to verified fields.
Vinony links it to 12 Wikipedia language editions.
Chemical data
- Formula
- C8H9N3O4
- Molecular weight
- 211.17 g/mol
- IUPAC name
- 2-(pyridine-3-carbonylamino)ethyl nitrate
- SMILES
- C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-]
- InChIKey
- LBHIOVVIQHSOQN-UHFFFAOYSA-N
- XLogP
- 0.8
- Polar surface area
- 97 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, myocardial infarction, Dementia, COVID-19
via ChEMBL · EBI
Research
1,985 papers- Nicorandil alleviates cardiac microvascular ferroptosis in diabetic cardiomyopathy: Role of the mitochondria-localized AMPK-Parkin-ACSL4 signaling pathway.Pharmacological research · 2024
- Nicorandil: animal pharmacology.The American journal of cardiology · 1989
- Nicorandil-associated ulcerations.European journal of gastroenterology & hepatology · 2007
- Nicorandil - an Effective Multitarget Drug for Cardioprotection?Cardiovascular drugs and therapy · 2023
- Nicorandil: A drug with ongoing benefits and different mechanisms in various diseased conditions.Indian journal of pharmacology · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 211.059306
- Has use
- medication
Show 7 more facts
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Side effects
- Mechanism of action
- Synthesis
- Names
- Brand names
- References
- Further reading
Nicorandil is a vasodilator drug used to treat angina, which is chest pain that results from episodes of transient myocardial ischemia. Angina can be caused by diseases such as atherosclerosis, coronary artery disease, and aortic stenosis.
It was patented in 1976 and approved for medical use in 1983.
Excerpted from Wikipedia’s “nicorandil” article, available under the CC BY-SA 4.0 licence.