norfenefrine

Also known as meta-Octopamine, 3-Octopamine, m-Octopamine

Norfenefrine, also known as '''meta-octopamine or norphenylephrine and sold under the brand name Novadral' among others, is a sympathomimetic medication which is used in the treatment of hypotension (low blood pressure). Along with its structural isomer p''-octopamine and the tyramines, norfenefrine is a naturally occurring endogenous trace amine and plays a role as a minor neurotransmitter in the brain.

In the Vinony graph

Within Vinony's link graph, norfenefrine is referenced by 1,517 other articles, and connects out to adrenergic receptor, epinephrine and propranolol.

It is catalogued under topics including 3-Hydroxyphenyl compounds, Alpha-adrenergic agonists and Antihypotensive agents.

Its subject is documented across 12 Wikipedia language editions.

Key facts

Drug.N: 1
Drug.O: 2
Drug.Verifiedfields: changed
Drug.verifiedrevid: 462263073
Drug.image: Norfenefrine.png
Drug.image_class: skin-invert-image
Drug.width: 200px
Drug.image2: (R)-Norfenefrine molecule ball.png
Drug.image_class2: bg-transparent
Drug.width2: 200px
Drug.alt2: Ball-and-stick model of (R)-Norfenefrine
Drug.legal_status: Rx-only
Drug.metabolism: m-Hydroxymandelic acid
Drug.CAS_number: 536-21-0
Drug.CAS_supplemental: 15308-34-6 (hydrochloride)
Drug.ATC_prefix: C01
Drug.ATC_suffix: CA05
Drug.PubChem: 4538

via Wikipedia infobox

Research

101 papers

Norfenefrine in the treatment of female stress incontinence. A double-blind controlled trial.Urologia internationalis · 1988
Norfenefrine: haemodynamic effects in healthy volunteers at rest and during orthostasis.European journal of clinical pharmacology · 1983
Norfenefrine in the treatment of female urinary stress incontinence assessed by one-hour pad weighing test.Urologia internationalis · 1989
In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects.The Journal of pharmacology and experimental therapeutics · 2002
Evidence for neuronal uptake and release of norfenefrine and evaluation of its alpha-agonistic effects in the rabbit pulmonary artery.Arzneimittel-Forschung · 1984

via PubMed

Wikidata facts

Mass: 153.079

Show 4 more facts

chemical formula: C₈H₁₁NO₂
canonical SMILES: C1=CC(=CC(=C1)O)C(CN)O
Commons category: Norfenefrine
defined daily dose: 25

Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

8 sections

Contents

Medical uses
Pharmacology
Pharmacodynamics
Chemistry
Society and culture
Names
Availability
References

Norfenefrine, also known as '''meta-octopamine or norphenylephrine and sold under the brand name Novadral' among others, is a sympathomimetic medication which is used in the treatment of hypotension (low blood pressure). Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring endogenous trace amine and plays a role as a minor neurotransmitter in the brain.

==Medical uses== Norfenefrine is used in the treatment of hypotension (low blood pressure). It is said to be similarly effective or less effective than midodrine.

Excerpted from Wikipedia’s “norfenefrine” article, available under the CC BY-SA 4.0 licence.