norgestrel

Also known as DL-norgestrel

Norgestrel, sold under the brand name Opill among others, is a progestin which is used in birth control pills. It is often combined with the estrogen ethinylestradiol, marketed as Ovral. It is also used in menopausal hormone therapy. It is taken by mouth.

Key facts

Drug.Verifiedfields: verified
Drug.Watchedfields: verified
Drug.verifiedrevid: 456663702
Drug.image: Levonorgestrel.svg
Drug.image_class: skin-invert-image
Drug.width: 225
Drug.image2: Dextronorgestrel.svg
Drug.image_class2: skin-invert-image
Drug.width2: 225
Drug.caption: Top, levonorgestrel (CAS ); Bottom: dextronorgestrel (CAS ). <!--
Drug.image3: Norgestrel molecule ball.png
Drug.width3: 225
Drug.alt3: -->
Drug.tradename: Opill, others
Drug.MedlinePlus: a602008
Drug.DailyMedID: Norgestrel
Drug.routes_of_administration: By mouth
Drug.class: Progestin

via Wikipedia infobox

Research

7,293 papers

Norgestrel 0.075 mg (Opill) for Contraception.American family physician · 2024
A review of the effectiveness of a progestogen-only pill containing norgestrel 75 µg/day.Contraception · 2022
Norgestrel.IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans · 1979
A D-norgestrel-releasing IUD.Contraception · 1976
Norgestrel (Opill) Is the First Over-the-Counter Oral Contraceptive Pill Approved in the United States.Nursing for women's health · 2024

via PubMed

Wikidata facts

Mass: 312.20893

Show 4 more facts

chemical formula: C₂₁H₂₈O₂
canonical SMILES: CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
isomeric SMILES: CC[C@]12CC[C@H]3[C@H]([C@@H]1CCC2(C#C)O)CCC4=CC(=O)CC[C@H]34
Commons category: Norgestrel

Sources (3)

via Wikidata · CC0

~7 min read

Article

13 sections

Contents

Medical uses
Side effects
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
Synthesis
History
Society and culture
Generic names
Brand names
See also
References

Side effects of norgestrel include menstrual irregularities, headaches, nausea, and breast tenderness. The most common side effects of the norgestrel include irregular bleeding, headaches, dizziness, nausea, increased appetite, abdominal pain, cramps, or bloating. Norgestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak androgenic activity and no other important hormonal activity.