OPTN
Sign in to saveAlso known as ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, optineurin
Optineurin is a protein that in humans is encoded by the OPTN gene.
Gene data
OPTN- Name
- optineurin
- Type
- protein-coding
- Position
- 13,099,449–13,140,320 (+)
- Aliases
- ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
- Ensembl
- ENSG00000123240
- RefSeq RNA
- NM_001008211.1, NM_001008212.2, NM_001008213.1, NM_021980.4
- RefSeq protein
- NP_001008212.1, NP_001008213.1, NP_001008214.1, NP_068815.2
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
optineurin
- Symbol
- OPTN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:13,099,442-13,159,480
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 11085
- exact match
- identifiers.org/ncbigene/10133
- genomic end
- 13180291
- genomic start
- 13141449
- cytogenetic location
- 10p13
- Commons category
- Optineurin
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
Optineurin is a protein that in humans is encoded by the OPTN gene.
== Function ==