RAB8A

Also known as MEL, RAB8, RAB8A, member RAS oncogene family

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.

In the Vinony graph

Vinony's link graph records 13 inbound references to RAB8A, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 19.

Vinony links it to 7 Wikipedia language editions.

Gene data

RAB8A

Name: RAB8A, member RAS oncogene family
Type: protein-coding
Position: 16,111,653–16,134,235 (+)
Aliases: MEL, RAB8
Ensembl: ENSG00000167461
RefSeq RNA: NM_005370.5
RefSeq protein: NP_005361.2

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008].