RAB8A

Name

RAB8A, member RAS oncogene family

Type

protein-coding

Position

16,111,843–16,134,234 (+)

Aliases

MEL, RAB8

Ensembl

ENSG00000167461

RefSeq RNA

NM_005370.5

RefSeq protein

NP_005361.2

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

RAB8A, member RAS oncogene family

Symbol

RAB8A

Biotype

Protein coding

Organism

Homo sapiens

Location

19:16,111,653-16,134,235

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein RAB8A PDB 2fu5.png

via Wikidata · CC0