orforglipron
Sign in to saveOrforglipron, sold under the brand name Foundayo, is an oral, non-peptide, small-molecule GLP-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company. It was discovered by Chugai Pharmaceutical Co., then was licensed to Lilly in 2018.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 882.377721076
- Manufacturer
- Eli Lilly and Company
Show 4 more facts
- Commons category
- Orforglipron
- isomeric SMILES
- Cc1cc(-n2nc3c(c2-n2ccn(-c4ccc5c(cnn5C)c4F)c2=O)[C@H](C)N(C(=O)c2cc4cc([C@H]5CCOC(C)(C)C5)ccc4n2[C@@]2(c4nc(=O)o[nH]4)C[C@@H]2C)CC3)cc(C)c1F
- chemical formula
- C₄₈H₄₈F₂N₁₀O₅
- canonical SMILES
- Cc1cc(-n2nc3c(c2-n2ccn(-c4ccc5c(cnn5C)c4F)c2=O)C(C)N(C(=O)c2cc4cc(C5CCOC(C)(C)C5)ccc4n2C2(c4nc(=O)o[nH]4)CC2C)CC3)cc(C)c1F
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Encyclopedic overview
6 sectionsContents
- Mechanism of action
- Clinical trials
- Phase III ACHIEVE-1 trial
- See also
- References
- External links
Orforglipron, sold under the brand name Foundayo, is an oral, non-peptide, small-molecule GLP-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company. It was discovered by Chugai Pharmaceutical Co., then was licensed to Lilly in 2018.
Orforglipron is easier to produce than existing peptide GLP-1 agonists and is expected to be cheaper.
Excerpted from Wikipedia’s “orforglipron” article, available under the CC BY-SA 4.0 licence.