Structure via PubChem · Public domain (PubChem)
oxaliplatin
Sign in to saveAlso known as SR-96669, Eloxatin, JM-83, RP-54780, L-OHP, Diaminocyclohexane Oxalatoplatinum, Oxalatoplatin, Oxalatoplatinum
Oxaliplatin, sold under the brand name Eloxatin among others, is a cancer medication (platinum-based antineoplastic class) used to treat colorectal cancer. It is given by infusion into a vein.
Chemical data
- Formula
- C8H12N2O4Pt
- Molecular weight
- 395.28 g/mol
- IUPAC name
- [(1R,2R)-2-azanidylcyclohexyl]azanide;oxalate;platinum(4+)
- SMILES
- C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)[O-])[O-].[Pt+4]
- InChIKey
- DWAFYCQODLXJNR-BNTLRKBRSA-L
- Polar surface area
- 82.3 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
18,717 papers- PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer.Nature communications · 2023
- USP10/XAB2/ANXA2 axis promotes DNA damage repair to enhance chemoresistance to oxaliplatin in colorectal cancer.Journal of experimental & clinical cancer research : CR · 2025
- Oxaliplatin: Detection and Management of Hypersensitivity Reactions.Clinical journal of oncology nursing · 2019
- Modified Fluorouracil, Leucovorin, Irinotecan, and Oxaliplatin or S-1, Irinotecan, and Oxaliplatin Versus Nab-Paclitaxel + Gemcitabine in Metastatic or Recurrent Pancreatic Cancer (GENERATE, JCOG1611): A Randomized, Open-Label, Phase II/III Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
- Oxaliplatin-safety profile: neurotoxicity.Seminars in oncology · 2003
via PubMed
Wikidata facts
- Subclass of
- platinum-based antineoplastic
- Has part
- platinum
- Mass
- 395.04449796399996
- Manufacturer
- Pfizer
- Has use
- medication
Show 9 more facts
- route of administration
- intravenous infusion and defusion
- medical condition treated
- rectum cancer
- chemical formula
- C₈H₁₂N₂O₄Pt
- Commons category
- Oxaliplatin
- isomeric SMILES
- O=C1O[Pt]2(N[C@@H]3CCCC[C@H]3N2)OC1=O
- NCI Thesaurus ID
- C1181
- subject has role
- essential medicine
- canonical SMILES
- O=C1O[Pt]2(NC3CCCCC3N2)OC1=O
- legal status (medicine)
- boxed warning
Sources (7)
via Wikidata · CC0
~5 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Advanced colorectal cancer
- Adverse effects
- Structure and mechanism
- History
- Patent information
- References
- Further reading
- External links
Oxaliplatin, sold under the brand name Eloxatin among others, is a cancer medication (platinum-based antineoplastic class) used to treat colorectal cancer. It is given by infusion into a vein.
Common side effects include numbness, feeling tired, nausea, diarrhea, and low blood cell counts. Other serious side effects include allergic reactions. Use in pregnancy is known to harm the baby. Oxaliplatin is in the platinum-based antineoplastic family of medications. It is believed to work by blocking the duplication of DNA.
Excerpted from Wikipedia’s “oxaliplatin” article, available under the CC BY-SA 4.0 licence.