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perilipin 1
Sign in to saveAlso known as PLIN1, lipid droplet-associated protein, perilipin-1
Perilipin, also known as lipid droplet-associated protein, perilipin 1, or PLIN, is a protein that, in humans, is encoded by the PLIN gene. The perilipins are a family of proteins that associate with the surface of lipid droplets. Phosphorylation of perilipin is essential for the mobilization of fats in adipose tissue.
Protein · UniProt
Perilipin-1
- Gene
- PLIN1
- Organism
- Homo sapiens (Human)
- Length
- 522 aa
- Molecular mass
- 55,990 Da
- Evidence
- 1: Evidence at protein level
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels
Swiss-Prot (reviewed) · via UniProt
Research
820 papers- Perilipin 1: a systematic review on its functions on lipid metabolism and atherosclerosis in mice and humans.Cardiovascular research · 2024
- The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017
- Anti-perilipin-1 autoantibodies in autoimmune Addison's disease and related endocrine disorders.Autoimmunity · 2025
- Molecular mechanisms of perilipin protein function in lipid droplet metabolism.FEBS letters · 2024
- Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy.Diabetes · 2023
via PubMed
Clinical Trials
1 registered- NACOMPLETEDComparison of Perilipin, Leptin, Adipolipin, Adiponectin, Resistin, Visfatin, Estrone Levels Pre-post OmentectomyIstanbul Training and Research Hospital · NCT03258307
~8 min read
Encyclopedic overview
12 sectionsContents
- Perilipin family of proteins
- Evolution
- Composition and structure
- Human perilipin
- Murine perilipin
- Function
- Modulator of adipocyte lipid metabolism
- Clinical significance
- Overexpression
- Deficiency
- References
- Further reading
Perilipin, also known as lipid droplet-associated protein, perilipin 1, or PLIN, is a protein that, in humans, is encoded by the PLIN gene. The perilipins are a family of proteins that associate with the surface of lipid droplets. Phosphorylation of perilipin is essential for the mobilization of fats in adipose tissue.
== Perilipin family of proteins == Perilipin is part of a gene family with six currently-known members. In vertebrates, closely related genes include adipophilin (also known as adipose differentiation-related protein or Perilipin 2), TIP47 (Perilipin 3), Perilipin 4 and Perilipin 5 (also called MLDP, LSDP5, or OXPAT). Insects express related proteins, LSD1 and LSD2, in fat bodies. The yeast Saccharomyces cerevisiae expresses PLN1 (formerly PET10), that stabilizes lipid droplets and aids in their assembly.
Excerpted from Wikipedia’s “perilipin 1” article, available under the CC BY-SA 4.0 licence.