phenformin
Sign in to saveAlso known as DBI, Fenformin, β-Phenethybiguanide, Fenformina, Phenformine, Phenforminum
Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases.
Research
1,924 papers- Phenformin as an Anticancer Agent: Challenges and Prospects.International journal of molecular sciences · 2019
- A review of phenformin, metformin, and imeglimin.Drug development research · 2020
- [Phenformin].Journees annuelles de diabetologie de l'Hotel-Dieu · 1967
- Phenformin: AMP(K)ed for Potential Repurposing.The Journal of investigative dermatology · 2021
- Progress in antitumor mechanisms and applications of phenformin (Review).Oncology reports · 2024
via PubMed
Wikidata facts
- Mass
- 205.133
Show 6 more facts
- chemical formula
- C₁₀H₁₅N₅
- canonical SMILES
- C1=CC=C(C=C1)CCN=C(N)N=C(N)N
- World Health Organisation international non-proprietary name
- phenformin
- defined daily dose
- 0.1
- isomeric SMILES
- [H]/N=C(/N)\N/C(=N/[H])/NCCc1ccccc1
- Commons category
- Phenformin
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Article
6 sectionsContents
- Toxicity
- Chemistry and pharmacokinetics
- Research
- Antiviral activity
- See also
- References
Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases.
Phenformin was developed in 1957 by Ungar, Freedman and Seymour Shapiro, working for the U.S. Vitamin Corporation. Clinical trials begun in 1958 showed it to be effective, but with gastrointestinal side effects.
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