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Phenylpropylaminopentane
Sign in to save1-Phenyl-2-propylaminopentane (PPAP), also known as 'α,N-dipropylphenethylamine (DPPEA) and by the developmental code name MK-306', is an experimental drug related to selegiline which acts as a catecholaminergic activity enhancer (CAE).
Chemical data
- Formula
- C14H23N
- Molecular weight
- 205.34 g/mol
- IUPAC name
- 1-phenyl-N-propylpentan-2-amine
- SMILES
- CCCC(CC1=CC=CC=C1)NCCC
- InChIKey
- PBENSVGEGPJNFJ-UHFFFAOYSA-N
- XLogP
- 4
- Polar surface area
- 12 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 205.183049736
Show 3 more facts
- chemical formula
- C₁₄H₂₃N
- canonical SMILES
- CCCC(CC1=CC=CC=C1)NCCC
- Commons category
- Phenylpropylaminopentane
via Wikidata · CC0
~8 min read
Encyclopedic overview
14 sectionsContents
- Pharmacology
- Pharmacodynamics
- Catecholaminergic activity enhancer
- Catecholamine reuptake inhibitor
- Other actions
- Chemistry
- History
- Society and culture
- Legal status
- Sweden
- Research
- See also
- References
- External links
1-Phenyl-2-propylaminopentane (PPAP), also known as 'α,N-dipropylphenethylamine (DPPEA) and by the developmental code name MK-306', is an experimental drug related to selegiline which acts as a catecholaminergic activity enhancer (CAE).
PPAP is a CAE and enhances the nerve impulse propagation-mediated release of norepinephrine and dopamine. It produces psychostimulant-like effects in animals. In 2025, it was discovered that PPAP is a potent catecholamine reuptake inhibitor, including of dopamine and to a lesser extent of norepinephrine. The drug is a phenethylamine and amphetamine derivative and was derived via structural modification of selegiline.
Excerpted from Wikipedia’s “Phenylpropylaminopentane” article, available under the CC BY-SA 4.0 licence.