phloretin

Also known as 4-O-Methylphloracetophenone, 2,6-Dihydroxy-4-methoxyacetophenone, Dihydronaringenin, Phloretol, 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE

Phloretin is a dihydrochalcone, a type of natural phenol. It can be found in apple tree leaves and the Manchurian apricot.

Research

2,499 papers

Phloretin, as a Potent Anticancer Compound: From Chemistry to Cellular Interactions.Molecules (Basel, Switzerland) · 2022
Phloretin: a comprehensive review of its potential against diabetes and associated complications.The Journal of pharmacy and pharmacology · 2024
Dermatological applications of the flavonoid phloretin.European journal of pharmacology · 2020
Biochemical Basis of Anti-Cancer-Effects of Phloretin-A Natural Dihydrochalcone.Molecules (Basel, Switzerland) · 2019
Phloretin-induced cytoprotective effects on mammalian cells: A mechanistic view and future directions.BioFactors (Oxford, England) · 2016

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Wikidata facts

Mass: 274.084

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chemical formula: C₁₅H₁₄O₅
canonical SMILES: C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O

Sources (4)

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Article

6 sections

Contents

Metabolism
Pharmacological research
Nanoparticle synthesis
Glycosides
See also
References

Phloretin is a dihydrochalcone, a type of natural phenol. It can be found in apple tree leaves and the Manchurian apricot.

== Metabolism == In rats, ingested phlorizin is converted into phloretin by hydrolytic enzymes in the small intestine. Phloretin hydrolase hydrolyses phloretin into phloretic acid and phloroglucinol.