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pivagabine
Sign in to savePivagabine (INN; brand name Tonerg), also known as '''N-pivaloyl-γ-aminobutyric acid or N-pivaloyl-GABA''', is an antidepressant and anxiolytic drug which was introduced in Italy in 1997 for the treatment of depressive and maladaptive syndromes. But it was discontinued in Italy (according to Martindale). Originally believed to function as a prodrug to GABA, pivagabine is now believed to act somehow via modulation of corticotropin-releasing factor (CRF).
Chemical data
- Formula
- C9H17NO3
- Molecular weight
- 187.24 g/mol
- IUPAC name
- 4-(2,2-dimethylpropanoylamino)butanoic acid
- SMILES
- CC(C)(C)C(=O)NCCCC(=O)O
- InChIKey
- SRPNQDXRVRCTNK-UHFFFAOYSA-N
- XLogP
- 0.8
- Polar surface area
- 66.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- anxiety, major depressive disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 187.121
Show 2 more facts
- chemical formula
- C₉H₁₇NO₃
- canonical SMILES
- CC(C)(C)C(=O)NCCCC(=O)O
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Pivagabine (INN; brand name Tonerg), also known as '''N-pivaloyl-γ-aminobutyric acid or N-pivaloyl-GABA''', is an antidepressant and anxiolytic drug which was introduced in Italy in 1997 for the treatment of depressive and maladaptive syndromes. But it was discontinued in Italy (according to Martindale). Originally believed to function as a prodrug to GABA, pivagabine is now believed to act somehow via modulation of corticotropin-releasing factor (CRF).
==See also== Fengabine
Excerpted from Wikipedia’s “pivagabine” article, available under the CC BY-SA 4.0 licence.