pleiotropy
Sign in to saveAlso known as pleiotropism, genetic pleiotropy
thumb|Simple genotype–phenotype map that only shows additive pleiotropy effects. G1, G2, and G3 are different genes that contribute to phenotypic traits P1, P2, and P3.
Research
10,873 papers- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020
- What Is Antagonistic Pleiotropy?Biochemistry. Biokhimiia · 2019
- Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders.Biological psychiatry · 2021
- A global overview of pleiotropy and genetic architecture in complex traits.Nature genetics · 2019
- Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.Nature genetics · 2018
via PubMed
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Article
32 sectionsContents
- History
- Mechanism
- Biological pleiotropy
- Single-gene pleiotropy
- Multigene regulatory pleiotropy
- Mediated pleiotropy
- Spurious pleiotropy
- Other
- Polygenicity-induced horizontal pleiotropy
- Network pleiotropy
- Polygenic risk scores and pleiotropy in complex traits
- Models for the origin
- Evolution
- Antagonistic pleiotropy
- Examples
- Human
- Albinism
- Phenylketonuria (PKU)
- Sickle cell anemia
- Marfan syndrome
- Pain susceptibility
- Animals
- Chickens
- Pleiotropy in psychiatry
- Autism and schizophrenia
- Model organisms
- "Mini-muscle" allele
- Cellular functions and DNA repair
- DNA repair proteins
- See also
- References
- External links
thumb|Simple genotype–phenotype map that only shows additive pleiotropy effects. G1, G2, and G3 are different genes that contribute to phenotypic traits P1, P2, and P3.
Pleiotropy () is a condition in which a single gene or genetic variant influences multiple phenotypic traits. A gene that has such multiple effects is referred to as a pleiotropic gene. Mutations in pleiotropic genes can affect several traits simultaneously, often because the gene product is used in various cells and affects different biological targets through shared signaling pathways.