PM20D1
Sign in to saveAlso known as Cps1, peptidase M20 domain containing 1
Peptidase M20 domain containing 1 is a circulating enzyme which in humans is encoded by the PM20D1 gene. PM20D1 regulates bioactive N-acyl amide lipids and has been implicated in obesity, type 2 diabetes, pain, and Alzheimer's disease.
In the Vinony graph
Vinony's link graph records 3 inbound references to PM20D1, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 5 Wikipedia language editions.
Gene data
PM20D1- Name
- peptidase M20 domain containing 1
- Type
- protein-coding
- Position
- 205,825,657–205,850,133 (−)
- Aliases
- Cps1
- Ensembl
- ENSG00000162877
- RefSeq RNA
- NM_152491.5, NR_135186.2
- RefSeq protein
- NP_689704.4
Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including amide biosynthetic process; cellular amide catabolic process; and negative regulation of neuron death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
peptidase M20 domain containing 1
- Symbol
- PM20D1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:205,825,657-205,850,133
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 65049
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/148811
- genomic end
- 205819260
- genomic start
- 205828025
- chromosome
- human chromosome 1
- cytogenetic location
- 1q32.1
- expressed in
- body of stomach
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Function
- Clinical significance
- References
Peptidase M20 domain containing 1 is a circulating enzyme which in humans is encoded by the PM20D1 gene. PM20D1 regulates bioactive N-acyl amide lipids and has been implicated in obesity, type 2 diabetes, pain, and Alzheimer's disease.
== Function == PM20D1 catalyzes the biosynthesis of N-fatty acyl amino acids from free fatty acids and free amino acids. Consequently PM20D1 is involved in the generation of potent bioactive lipid metabolites from two abundant cellular energy precursors.
Excerpted from Wikipedia’s “PM20D1” article, available under the CC BY-SA 4.0 licence.