praziquantel

Also known as EMBAY-8440

Praziquantel, sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. In humans specifically, it is used to treat schistosomiasis, clonorchiasis, opisthorchiasis, tapeworm infections, cysticercosis, echinococcosis, paragonimiasis, fasciolopsiasis, and fasciolosis. It should not be used for worm infections of the eye. It is taken by mouth.

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 464213440
Drug.image: Praziquantel enantiomers labelled.svg
Drug.image_class: skin-invert-image
Drug.width: 300
Drug.imageL: (R)-praziquantel-from-xtal-3D-bs-17.png
Drug.image_classL: bg-transparent
Drug.widthL: 150
Drug.imageR: (S)-praziquantel-from-xtal-3D-bs-17.png
Drug.image_classR: bg-transparent
Drug.widthR: 150
Drug.tradename: Biltricide
Drug.MedlinePlus: a608048
Drug.DailyMedID: Praziquantel
Drug.pregnancy_AU: B1
Drug.routes_of_administration: by mouth
Drug.ATC_prefix: P02
Drug.ATC_suffix: BA01

via Wikipedia infobox

Chemical data

Formula: C19H24N2O2
Molecular weight: 312.4 g/mol
IUPAC name: 2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
SMILES: C1CCC(CC1)C(=O)N2CC3C4=CC=CC=C4CCN3C(=O)C2
InChIKey: FSVJFNAIGNNGKK-UHFFFAOYSA-N
XLogP: 2.7
Polar surface area: 40.6 Å²
H-bond donors: 0
H-bond acceptors: 2
Formal charge: 0

via PubChem

Research

7,463 papers

Praziquantel.Parasitology research · 2003
Praziquantel.Medicinal research reviews · 1983
Praziquantel: An Enigmatic, Yet Effective, Drug.Methods in molecular biology (Clifton, N.J.) · 2020
Praziquantel use in aquaculture - Current status and emerging issues.International journal for parasitology. Drugs and drug resistance · 2022
Praziquantel.Advances in pharmacology and chemotherapy · 1984

via PubMed

~14 min read

Encyclopedic overview

13 sections

Contents

Medical uses
Side effects
Pregnancy
Drug interactions
Mechanism of action
Pharmacokinetics
History
Society and culture
Brand names
Regulatory approval
Veterinary medicine
References
External links

Side effects in humans may include poor coordination, abdominal pain, vomiting, headache, and allergic reactions. While it may be used during pregnancy, it is not recommended for use during breastfeeding. Praziquantel is in the anthelmintic class of medications. It works partly by affecting the function of the worm's sucker.

Excerpted from Wikipedia’s “praziquantel” article, available under the CC BY-SA 4.0 licence.

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