promegestone

Also known as R5020, 17,21-dimethyl-19-norpregna-4,9(10)-diene-3,20-dione, R 5020, 17alpha-methyl-17-propionylestra-4,9-dien-3-one, RU5020

Promegestone, sold under the brand name Surgestone, is a progestin medication which is used in menopausal hormone therapy and in the treatment of gynecological disorders. It is taken by mouth.

Chemical data

Formula: C22H30O2
Molecular weight: 326.5 g/mol
IUPAC name: (8S,13S,14S,17S)-13,17-dimethyl-17-propanoyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

837 papers

Use of progestogens and the risk of intracranial meningioma: national case-control study.BMJ (Clinical research ed.) · 2024
Promegestone Prevents Lipopolysaccharide-Induced Cervical Remodeling in Pregnant Mice.Cells · 2025
The selective progesterone receptor modulator-promegestone-delays term parturition and prevents systemic inflammation-mediated preterm birth in mice.American journal of obstetrics and gynecology · 2022
Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells.The Journal of clinical endocrinology and metabolism · 1998
[Promegestone, a new progestin].Journal de gynecologie, obstetrique et biologie de la reproduction · 1983

via PubMed

Wikidata facts

Mass: 326.225

Show 5 more facts

chemical formula: C₂₂H₃₀O₂
canonical SMILES: CCC(=O)C1(CCC2C1(CCC3=C4CCC(=O)C=C4CCC23)C)C
isomeric SMILES: CCC(=O)[C@]1(CC[C@@H]2[C@@]1(CCC3=C4CCC(=O)C=C4CC[C@@H]23)C)C
World Health Organisation international non-proprietary name: promegestone
Commons category: Promegestone

Sources (2)

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Article

13 sections

Contents

Medical uses
Side effects
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
History
Society and culture
Generic names
Brand names
Availability
References
Further reading

Promegestone, sold under the brand name Surgestone, is a progestin medication which is used in menopausal hormone therapy and in the treatment of gynecological disorders. It is taken by mouth.

Side effects of promegestone include menstrual irregularities among others. Promegestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak antiandrogenic, glucocorticoid, and antimineralocorticoid activity and no other important hormonal activity. The medication is largely a prodrug of trimegestone.