Structure via PubChem · Public domain (PubChem)
proxibarbal
Sign in to saveProxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956 in Poland by Bogusław Bobrański. It has anti-anxiety and sedative properties and is, in contrast to most barbiturates, almost without hypnotic action. It was used as a sedative and anti-anxiety drug. It was also used in the treatment of migraine headaches in a similar manner to butalbital. It was a prescription drug available in Poland from the 1950s to the 1990s under trade name Ipronal.
Chemical data
- Formula
- C10H14N2O4
- Molecular weight
- 226.23 g/mol
- IUPAC name
- 5-(2-hydroxypropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
18 papers- Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats.European journal of drug metabolism and pharmacokinetics · 1981
- Isomerisation and urinary excretion of proxibarbal and valofan in man; a preliminary study.European journal of drug metabolism and pharmacokinetics · 1984
- [Thrombopenic purpura caused by proxibarbal].La Revue de medecine interne · 1993
- [Development of proxibarbal blood levels. The role of various elimination processes].Journal de pharmacologie · 1984
- [A controlled trial of prevention of recurrence of gastroduodenal ulcers with proxybarbital].Polski tygodnik lekarski (Warsaw, Poland : 1960) · 1989
via PubMed
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956 in Poland by Bogusław Bobrański. It has anti-anxiety and sedative properties and is, in contrast to most barbiturates, almost without hypnotic action. It was used as a sedative and anti-anxiety drug. It was also used in the treatment of migraine headaches in a similar manner to butalbital. It was a prescription drug available in Poland from the 1950s to the 1990s under trade name Ipronal.
Valofane isomerizes to proxibarbal in vivo.
Excerpted from Wikipedia’s “proxibarbal” article, available under the CC BY-SA 4.0 licence.
Available in 10 languages
via Wikidata sitelinks · CC0