Structure via PubChem · Public domain (PubChem)
pyrithyldione
Sign in to savePyrithyldione (Presidon, Persedon) is a psychoactive drug invented in 1949. An improved method of manufacture was patented by Roche in 1959. It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates. Today, this substance is no longer used. Agranulocytosis was sometimes reported as adverse effect. Pyrithyldione is also a CYP2D6 inducer but is not as potent as glutethimide. In studies, it increased the O-demethylation of codeine by 20%.
Chemical data
- Formula
- C9H13NO2
- Molecular weight
- 167.2 g/mol
- IUPAC name
- 3,3-diethyl-1H-pyridine-2,4-dione
- SMILES
- CCC1(C(=O)C=CNC1=O)CC
- InChIKey
- NZASCBIBXNPDMH-UHFFFAOYSA-N
- XLogP
- 1
- Polar surface area
- 46.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 167.095
Show 3 more facts
- chemical formula
- C₉H₁₃NO₂
- canonical SMILES
- CCC1(C(=O)C=CNC1=O)CC
- Commons category
- Pyrithyldione
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Pyrithyldione (Presidon, Persedon) is a psychoactive drug invented in 1949. An improved method of manufacture was patented by Roche in 1959. It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates. Today, this substance is no longer used. Agranulocytosis was sometimes reported as adverse effect. Pyrithyldione is also a CYP2D6 inducer but is not as potent as glutethimide. In studies, it increased the O-demethylation of codeine by 20%.
== See also == Methyprylon Piperidione Glutethimide
Excerpted from Wikipedia’s “pyrithyldione” article, available under the CC BY-SA 4.0 licence.