Structure via PubChem · Public domain (PubChem)
pyrithyldione
Sign in to savePyrithyldione (Presidon, Persedon) is a psychoactive drug invented in 1949. An improved method of manufacture was patented by Roche in 1959. It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates. Today, this substance is no longer used. Agranulocytosis was sometimes reported as adverse effect. Pyrithyldione is also a CYP2D6 inducer but is not as potent as glutethimide. In studies, it increased the O-demethylation of codeine by 20%.
In the Vinony graph
Vinony's link graph records 590 inbound references to pyrithyldione, and connects out to barbiturates, benzodiazepine drug and isovaleric acid.
It is catalogued under topics including Chemical pages without DrugBank identifier, Drugboxes which contain changes to verified fields and Drugs with no legal status.
Vinony links it to 7 Wikipedia language editions.
Chemical data
- Formula
- C9H13NO2
- Molecular weight
- 167.2 g/mol
- IUPAC name
- 3,3-diethyl-1H-pyridine-2,4-dione
- SMILES
- CCC1(C(=O)C=CNC1=O)CC
- InChIKey
- NZASCBIBXNPDMH-UHFFFAOYSA-N
- XLogP
- 1
- Polar surface area
- 46.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 167.095
Show 3 more facts
- chemical formula
- C₉H₁₃NO₂
- canonical SMILES
- CCC1(C(=O)C=CNC1=O)CC
- Commons category
- Pyrithyldione
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Pyrithyldione (Presidon, Persedon) is a psychoactive drug invented in 1949. An improved method of manufacture was patented by Roche in 1959. It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates. Today, this substance is no longer used. Agranulocytosis was sometimes reported as adverse effect. Pyrithyldione is also a CYP2D6 inducer but is not as potent as glutethimide. In studies, it increased the O-demethylation of codeine by 20%.
== See also == Methyprylon Piperidione Glutethimide
Excerpted from Wikipedia’s “pyrithyldione” article, available under the CC BY-SA 4.0 licence.