pyrazinamide
Also known as Zinamide®, PZA, Pyrazine carboxamide, Pyrazineamide, Pirazinamida, Pyrazinamidum, Pirazinamide
Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. It is not generally recommended for the treatment of latent tuberculosis. It is taken by mouth.
Chemical data
- Formula
- C5H5N3O
- Molecular weight
- 123.11 g/mol
- IUPAC name
- pyrazine-2-carboxamide
- SMILES
- C1=CN=C(C=N1)C(=O)N
- InChIKey
- IPEHBUMCGVEMRF-UHFFFAOYSA-N
- XLogP
- -0.6
- Polar surface area
- 68.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
6,571 papersArticle
9 sectionsContents
- Medical uses
- Adverse effects
- Pharmacokinetics
- Mechanism of action
- Resistance
- Abbreviations
- Presentation
- History
- References
Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. It is not generally recommended for the treatment of latent tuberculosis. It is taken by mouth.
Common side effects include nausea, loss of appetite, muscle and joint pains, and rash. More serious side effects include gout, liver toxicity, and sensitivity to sunlight. It is not recommended in those with significant liver disease or porphyria. It is unclear if use during pregnancy is safe but it is likely okay during breastfeeding. Pyrazinamide is in the antimycobacterial class of medications. How it works is not entirely clear.