Thiocarlide
Sign in to saveThiocarlide (or tiocarlide or isoxyl) is a thiourea drug used in the treatment of tuberculosis, inhibiting synthesis of oleic acid and tuberculostearic acid.
Research
155 papers- [Thiocarlide. Attempt of an evaluation].Therapie der Gegenwart · 1969
- [On metabolites of thiocarlide].Helvetica chimica acta · 1969
- Clinical experience with thiocarlide (Isoxyl).Antibiotica et chemotherapia. Fortschritte. Advances. Progres · 1970
- A clinical trial of thiocarlide (4-4' diisoamyloxythiocarbanilide).Tubercle · 1966
- A Histoplasma capsulatum Lipid Metabolic Map Identifies Antifungal Targets.mBio · 2021
via PubMed
Wikidata facts
- Mass
- 400.218
Show 3 more facts
- chemical formula
- C₂₃H₃₂N₂O₂S
- Commons category
- Thiocarlide
- canonical SMILES
- CC(C)CCOC1=CC=C(C=C1)NC(=S)NC2=CC=C(C=C2)OCCC(C)C
Sources (2)
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Article
1 sectionsContents
- References
Thiocarlide (or tiocarlide or isoxyl) is a thiourea drug used in the treatment of tuberculosis, inhibiting synthesis of oleic acid and tuberculostearic acid.
Thiocarlide has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis. Isoxyl inhibits M. bovis with six hours of exposure, which is similar to isoniazid and ethionamide, two other prominent anti-TB drugs. Unlike these two drugs, however, isoxyl also partially inhibits the synthesis of fatty acids.
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