rifamycin
Sign in to saveAlso known as rifamycins
The rifamycins are a group of antibiotics that are synthesized either naturally by the bacterium Amycolatopsis rifamycinica or artificially. They are a subclass of the larger family of ansamycins. Rifamycins are particularly effective against mycobacteria, and are therefore used to treat tuberculosis, leprosy, and mycobacterium avium complex (MAC) infections.
Key facts
- Drug.StdInChI
- 1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
- Drug.StdInChIKey
- HJYYPODYNSCCOU-ODRIEIDWSA-N
- Drug.image
- Rifamycin SV.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Rifamycin SV stick 6BEB.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Aemcolo
- Drug.MedlinePlus
- a619010
- Drug.DailyMedID
- Rifamycin
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- A07
- Drug.ATC_suffix
- AA13
- Drug.legal_US
- Rx-only
- Drug.index2_label
- as salt
- Drug.CAS_number
- 6998-60-3
- Drug.PubChem
- 6324616
- Drug.DrugBank
- DB11753
- Drug.ChemSpiderID
- 16735998
via Wikipedia infobox
Research
26,400 papers- Rifamycin SV MMX(®): A Review in the Treatment of Traveller's Diarrhoea.Clinical drug investigation · 2019
- Rifamycin SV MMX for the treatment of traveler's diarrhea.Expert opinion on pharmacotherapy · 2017
- Rifamycin SV. A review.Arzneimittel-Forschung · 1965
- Rifamycin SV and related ansamycins.Biotechnology (Reading, Mass.) · 1995
- A Phase II, Multicentric, Randomized, Double-Blind, Placebo-Controlled, Proof of Concept Study of Efficacy and Safety of Rifamycin SV-MMX 600 mg Tablets Administered Three or Two Times Daily to Patients With Diarrhea-Predominant Irritable Bowel Syndrome.The American journal of gastroenterology · 2024
via PubMed
Clinical Trials
17 registered- PHASE3COMPLETEDRifamycin SV-MMX® Tablets Versus Ciprofloxacin Capsules in Acute Traveller's DiarrhoeaDr. Falk Pharma GmbH · NCT01208922
- PHASE1COMPLETEDDoravirine, Rifapentine and Isoniazid InteractionWalter K. Kraft · NCT03886701
- PHASE4UNKNOWNEvaluation of the Effects of Irrigation of the Extraction Socket With RifamycineYuzuncu Yil University · NCT04349579
- PHASE2COMPLETEDEfficacy and Safety of CB-01-11 200mg Tablets in Infectious DiarrhoeaCosmo Technologies Ltd · NCT03447821
- PHASE1COMPLETEDPharmacokinetics and Safety Study of Rifamycin SV-MMX® 600 mg Tablets After Single and Multiple t.i.d. Doses in Healthy Male and Female VolunteersCosmo Technologies Ltd · NCT02969252
- PHASE2/PHASE3RECRUITINGAssessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBICenters for Disease Control and Prevention · NCT03474029
Wikidata facts
- Instance of
- medication
- Subclass of
- ansamycin
Show 4 more facts
- topic's main category
- Category:Rifamycin antibiotics
- Commons category
- Rifamycin antibiotics
- subject has role
- antibiotic
- different from
- rifampicin
Sources (2)
via Wikidata · CC0
~9 min read
Encyclopedic overview
9 sectionsContents
- Bacterium
- First drugs
- Clinical trials
- Mechanism of action
- Biosynthesis
- Derivatives
- Available rifamycins
- References
- Further reading
The rifamycins are a group of antibiotics that are synthesized either naturally by the bacterium Amycolatopsis rifamycinica or artificially. They are a subclass of the larger family of ansamycins. Rifamycins are particularly effective against mycobacteria, and are therefore used to treat tuberculosis, leprosy, and mycobacterium avium complex (MAC) infections.
The rifamycin group includes the classic rifamycin drugs as well as the rifamycin derivatives rifampicin (or rifampin), rifabutin, rifapentine, rifalazil and rifaximin. Rifamycin, sold under the trade name Aemcolo, is approved in the United States for treatment of travelers' diarrhea in some circumstances.
Excerpted from Wikipedia’s “rifamycin” article, available under the CC BY-SA 4.0 licence.