aminocoumarin
Sign in to saveAlso known as aminocoumarins
thumb|Skeletal formula of [[novobiocin]] Aminocoumarin is a class of antibiotics that act by an inhibition of the DNA gyrase enzyme involved in the cell division in bacteria. They are derived from Streptomyces species, whose best-known representative – Streptomyces coelicolor – was completely sequenced in 2002. The aminocoumarin antibiotics include: Novobiocin, Albamycin (Pharmacia And Upjohn) Coumermycin Clorobiocin
In the Vinony graph
Within Vinony's link graph, aminocoumarin is referenced by 120 other articles, and connects out to sulfamethazine, antibiotic and fidaxomicin.
Vinony files it under Antibiotics and Coumarin drugs.
Its subject is documented across 7 Wikipedia language editions.
Research
2,586 papers- New aminocoumarin antibiotics as gyrase inhibitors.International journal of medical microbiology : IJMM · 2014
- Structural and functional dissection of aminocoumarin antibiotic biosynthesis: a review.Journal of structural and functional genomics · 2012
- The biosynthetic gene clusters of aminocoumarin antibiotics.Planta medica · 2006
- Genetically Encoded Aminocoumarin Lysine for Optical Control of Protein-Nucleotide Interactions in Zebrafish Embryos.ACS chemical biology · 2023
- Genome-mining-guided discovery of coumarubrin: A novel aminocoumarin-substituted rubromycin antibiotic.Journal of industrial microbiology & biotechnology · 2024
via PubMed
~2 min read
Encyclopedic overview
5 sectionsContents
- Structure
- Mechanism of action
- Resistance
- Clinical use
- References
thumb|Skeletal formula of [[novobiocin]] Aminocoumarin is a class of antibiotics that act by an inhibition of the DNA gyrase enzyme involved in the cell division in bacteria. They are derived from Streptomyces species, whose best-known representative – Streptomyces coelicolor – was completely sequenced in 2002. The aminocoumarin antibiotics include: Novobiocin, Albamycin (Pharmacia And Upjohn) Coumermycin Clorobiocin
==Structure== The core of aminocoumarin antibiotics is made up of a 3-amino-4,7-dihydroxycumarin ring, which is linked, e.g., with a sugar in 7-Position and a benzoic acid derivative in 3-Position.
Excerpted from Wikipedia’s “aminocoumarin” article, available under the CC BY-SA 4.0 licence.