File:Process_of_RNA_splicing.png · Wikimedia Commons · See Wikimedia Commons
RNA splicing
Sign in to saveAlso known as GO:0008380, splicing
the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA
Research
68,553 papers- RNA Splicing by the Spliceosome.Annual review of biochemistry · 2020
- RNA Splicing and Cancer.Trends in cancer · 2020
- Molecular impact of mutations in RNA splicing factors in cancer.Molecular cell · 2024
- RNA splicing as a therapeutic target in myelodysplastic syndromes.Seminars in hematology · 2024
- RNA splicing regulators play critical roles in neurogenesis.Wiley interdisciplinary reviews. RNA · 2022
via PubMed
Wikidata facts
- Instance of
- biological process
- Subclass of
- post-transcriptional modification
Show 3 more facts
- Commons category
- Splicing
- topic's main category
- Category:RNA splicing
- exact match
- purl.obolibrary.org/obo/GO_0008380
Sources (3)
via Wikidata · CC0
~19 min read
Encyclopedic overview
RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA (mRNA). It works by removing all the introns (non-coding regions of RNA) and splicing back together exons (coding regions). For nuclear-encoded genes, splicing occurs in the nucleus either during or immediately after transcription. For those eukaryotic genes that contain introns, splicing is usually needed to create an mRNA molecule that can be translated into protein. For many eukaryotic introns, splicing occurs in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs). There exist self-splicing introns, that is, ribozymes that can catalyze their own excision from their parent RNA molecule. The process of transcription, splicing and translation is called gene expression, the central dogma of molecular biology.
Process of RNA splicing
Excerpted from Wikipedia’s “RNA splicing” article, available under the CC BY-SA 4.0 licence.