RNASEL
Sign in to saveAlso known as PRCA1, RNS4, ribonuclease L
protein-coding gene in the species Homo sapiens
Gene data
RNASEL- Name
- ribonuclease L
- Type
- protein-coding
- Position
- 182,563,015–182,589,272 (−)
- Aliases
- PRCA1, RNS4
- Ensembl
- ENSG00000135828
- RefSeq RNA
- NM_021133.4, XM_047427096.1, XM_047427106.1, XM_054338068.1, XM_054338069.1
- RefSeq protein
- NP_066956.1, XP_047283052.1, XP_047283062.1, XP_054194043.1, XP_054194044.1
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
NOD-like receptor signaling pathway - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Influenza A - Homo sapiens (human)Herpes simplex virus 1 infection - Homo sapiens (human)Antimicrobial mechanism of IFN-stimulated genesCytokine Signaling in Immune systemImmune SystemOAS antiviral responseInterferon alpha/beta signalingInterferon Signaling
via MyGene.info
Gene · Ensembl
ribonuclease L
- Symbol
- RNASEL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:182,563,015-182,589,272
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein RNASEL PDB 1wdy.png
Show 8 more facts
- HomoloGene ID
- 8040
- genetic association
- multiple sclerosis
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6041
- genomic end
- 182558391
- genomic start
- 182542769
- chromosome
- human chromosome 1
- cytogenetic location
- 1q25.3
via Wikidata · CC0