RNF146

Also known as dJ351K20.1, ring finger protein 146, Ring finger protein 146, E3 ubiquitin-protein ligase RNF146, RING finger protein 146, RING-type E3 ubiquitin transferase RNF146, Iduna

RING finger protein 146 is a protein that in humans is encoded by the RNF146 gene.

In the Vinony graph

Within Vinony's link graph, RNF146 is referenced by 3 other articles, and connects out to PubMed, protein and Wikidata.

It sits within the topics Genes on human chromosome 10 and RING finger proteins.

Its subject is documented across 7 Wikipedia language editions.

Gene data

RNF146

Name: ring finger protein 146
Type: protein-coding
Position: 127,266,582–127,290,408 (+)
Ensembl: ENSG00000118518
RefSeq RNA: NM_001242844.2, NM_001242845.2, NM_001242846.2, NM_001242847.2, NM_001242848.2
RefSeq protein: NP_001229773.1, NP_001229774.1, NP_001229775.1, NP_001229776.1, NP_001229777.1

Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

Pathways

PIP3 activates AKT signaling Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Metabolism of proteins Degradation of AXIN Deubiquitination Ub-specific processing proteases Post-translational protein modification PTEN Regulation

via MyGene.info

Gene · Ensembl

ring finger protein 146

Symbol: RNF146
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:127,266,582-127,290,408
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Protein · UniProt

E3 ubiquitin-protein ligase RNF146

Gene: Rnf146
Organism: Mus musculus (Mouse)
Length: 359 aa
Molecular mass: 38,934 Da
Evidence: 1: Evidence at protein level

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds …

3D-structureCytoplasmIsopeptide bondMetal-bindingNucleusPhosphoproteinReference proteomeTransferase

View on UniProt →

Swiss-Prot (reviewed) · via UniProt