RNF7
Sign in to saveAlso known as CKBBP1, ROC2, SAG, ring finger protein 7, rbx2
RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.
Gene data
RNF7- Name
- ring finger protein 7
- Type
- protein-coding
- Position
- 141,738,249–141,747,560 (+)
- Aliases
- CKBBP1, ROC2, SAG, rbx2
- Ensembl
- ENSG00000114125
- RefSeq RNA
- NM_001201370.2, NM_014245.5, NM_183063.1, NM_183237.3, NR_037702.2
- RefSeq protein
- NP_001188299.1, NP_055060.1, NP_899060.1
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ring finger protein 7
- Symbol
- RNF7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:141,738,189-141,747,611
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- PDB 2ecl EBI.png
Show 5 more facts
- HomoloGene ID
- 84476
- genomic start
- 141738249
- exact match
- identifiers.org/ncbigene/9616
- genomic end
- 141466402
- cytogenetic location
- 3q23
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.