Gene data
RTN2- Name
- reticulon 2
- Type
- protein-coding
- Position
- 45,485,292–45,497,055 (−)
- Aliases
- HMNR11, NSP2, NSPL1, NSPLI, SPG12
- Ensembl
- ENSG00000125744
- RefSeq RNA
- NM_001445029.1, NM_001445030.1, NM_001445031.1, NM_001445032.1, NM_001445033.1
- RefSeq protein
- NP_001431958.1, NP_001431959.1, NP_001431960.1, NP_001431961.1, NP_001431962.1
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Reticulon proteins also play an important role in the replication of positive-strand RNA (ssRNA) viruses. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Aug 2020].
Gene Ontology
Biological process
brain developmentneuron differentiationregulation of D-glucose import across plasma membraneintracellular protein transmembrane transportendoplasmic reticulum tubular network formationnegative regulation of amyloid-beta formationnegative regulation of amyloid-beta formationendoplasmic reticulum tubular network membrane organization
Molecular function
via MyGene.info
Gene · Ensembl
reticulon 2
- Symbol
- RTN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:45,485,292-45,497,055
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 32180
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6253
- genomic end
- 45497055
- genomic start
- 45485294
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.32
Sources (3)
via Wikidata · CC0