SIRT2

Name

sirtuin 2

Type

protein-coding

Position

38,878,555–38,900,501 (−)

Aliases

SIR2, SIR2L, SIR2L2

Ensembl

ENSG00000283100

RefSeq RNA

NM_001193286.2, NM_012237.4, NM_030593.3, NR_034146.1, XM_011526655.2

RefSeq protein

NP_001180215.1, NP_036369.2, NP_085096.1, XP_011524957.1, XP_047294424.1

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010].

via MyGene.info

Gene · Ensembl

sirtuin 2

Symbol

SIRT2

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HG26_PATCH:288,227-309,534

Strand

Reverse (−)

Assembly

GRCh38