SNX5
Sign in to saveAlso known as sorting nexin 5
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
In the Vinony graph
Within Vinony's link graph, SNX5 is referenced by 24 other articles, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It sits within the topics Genes mutated in mice and Genes on human chromosome 20.
Its subject is documented across 5 Wikipedia language editions.
Gene data
SNX5- Name
- sorting nexin 5
- Type
- protein-coding
- Position
- 17,941,597–17,969,022 (−)
- Ensembl
- ENSG00000089006
- RefSeq RNA
- NM_001282454.2, NM_014426.4, NM_152227.3
- RefSeq protein
- NP_001269383.1, NP_055241.1, NP_689413.1
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sorting nexin 5
- Symbol
- SNX5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:17,941,597-17,969,022
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 40944
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27131
- genomic end
- 17949623
- genomic start
- 17922241
- chromosome
- human chromosome 20
- cytogenetic location
- 20p11.23
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.
Excerpted from Wikipedia’s “SNX5” article, available under the CC BY-SA 4.0 licence.