Structure via PubChem · Public domain (PubChem)
sonidegib
Sign in to saveAlso known as LDE225, erismodegib (deleted INN), LDE-225, NVP-LDE225, Odomzo®, NVP-LDE 225, LDE 225, Erismodegib
Sonidegib (INN), sold under the brand name Odomzo, is a medication used to treat cancer.
Chemical data
- Formula
- C26H26F3N3O3
- Molecular weight
- 485.5 g/mol
- IUPAC name
- N-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3-pyridinyl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2015
- Admin. routes
- oral
- Indications
- breast neoplasm, neoplasm, liver disease, medulloblastoma
via ChEMBL · EBI
Wikidata facts
- Mass
- 485.192626
Show 5 more facts
- chemical formula
- C₂₆H₂₆F₃N₃O₃
- canonical SMILES
- CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
- isomeric SMILES
- C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
- World Health Organisation international non-proprietary name
- sonidegib
- Commons category
- Sonidegib
Sources (6)
via Wikidata · CC0
~2 min read
Article
5 sectionsContents
- Approvals and indications
- Pharmacology
- Development
- References
- External links
Sonidegib (INN), sold under the brand name Odomzo, is a medication used to treat cancer.
Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism).
Connections
liver
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urine
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breast cancer
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digital object identifier
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leukemia
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chemical formula
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lymphatic system
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adaptive radiation therapy
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molar mass
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Q180686
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pancreatic cancer
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lymphoma
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apoptotic process
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ovarian cancer
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excretion
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bibcode
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CAS Registry Number
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Q229883
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PubChem
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Anatomical Therapeutic Chemical Classification System
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