sotalol

Also known as Betapace®, MJ-1999, beta-cardone, 4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide, Sotalolo, Sotalolum, 4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide

Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. Evidence does not support a decreased risk of death with long term use. It is taken by mouth or given by injection into a vein.

Chemical data

Formula: C12H20N2O3S
Molecular weight: 272.37 g/mol
IUPAC name: N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide
SMILES: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
InChIKey: ZBMZVLHSJCTVON-UHFFFAOYSA-N
XLogP: 0.2
Polar surface area: 86.8 Å²
H-bond donors: 3
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

3,568 papers

Sotalol.Cardiac electrophysiology clinics · 2016
Sotalol.The New England journal of medicine · 1994
Sotalol.Journal of cardiovascular electrophysiology · 1993
Does Sotalol Still Have a Role in the Management of Arrhythmias?American journal of therapeutics · 2019
Intravenous Sotalol: An Under Used Treatment Strategy.Cardiology · 2018

via PubMed

Wikidata facts

Mass: 272.119

Show 4 more facts

chemical formula: C₁₂H₂₀N₂O₃S
Commons category: Sotalol
canonical SMILES: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
World Health Organisation international non-proprietary name: sotalol

Sources (5)

via Wikidata · CC0

~9 min read

Article

13 sections

Contents

Medical uses
Contraindications
Adverse effects
Pharmacology
Mechanisms of action
Beta-blocker action
Type III antiarrhythmic action
Pharmacokinetics
Chemistry
History
Society and culture
Brand names
References

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