SPA17
Sign in to saveAlso known as CT22, SP17, SP17-1, sperm autoantigenic protein 17
Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to SPA17, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Vinony links it to 7 Wikipedia language editions.
Gene data
SPA17- Name
- sperm autoantigenic protein 17
- Type
- protein-coding
- Position
- 124,673,327–124,698,312 (+)
- Aliases
- CT22, SP17, SP17-1
- Ensembl
- ENSG00000064199
- RefSeq RNA
- NM_017425.4, XM_011542870.3, XM_024448583.2, XM_054369134.1, XM_054369135.1
- RefSeq protein
- NP_059121.1, XP_011541172.1, XP_024304351.1, XP_054225109.1, XP_054225110.1
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
sperm autoantigenic protein 17
- Symbol
- SPA17
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:124,673,327-124,698,312
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 7951
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/53340
- genomic start
- 124673844
- chromosome
- human chromosome 11
- genomic end
- 124567414
- cytogenetic location
- 11q24.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.
This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.
Excerpted from Wikipedia’s “SPA17” article, available under the CC BY-SA 4.0 licence.