Also known as CT22, SP17, SP17-1, sperm autoantigenic protein 17
Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009].
Biological process
Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.
This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.
Molecular function
via MyGene.info
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).