SPA17

Also known as CT22, SP17, SP17-1, sperm autoantigenic protein 17

Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.

Gene data

SPA17

Name: sperm autoantigenic protein 17
Type: protein-coding
Position: 124,673,796–124,698,309 (+)
Aliases: CT22, SP17, SP17-1
Ensembl: ENSG00000064199
RefSeq RNA: NM_017425.4, XM_011542870.3, XM_024448583.2, XM_054369134.1, XM_054369135.1
RefSeq protein: NP_059121.1, XP_011541172.1, XP_024304351.1, XP_054225109.1, XP_054225110.1

This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009].

Gene Ontology

Biological process

epithelial cilium movement involved in extracellular fluid movement spermatogenesis single fertilization single fertilization binding of sperm to zona pellucida

Molecular function

protein binding calmodulin binding

Cellular component

extracellular region cytoplasm cytoplasm cytoplasm cilium cilium external side of plasma membrane membrane

via MyGene.info

Gene · Ensembl

sperm autoantigenic protein 17

Symbol: SPA17
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:124,673,327-124,698,312
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 7951
exact match: identifiers.org/ncbigene/53340
genomic start: 124673844
genomic end: 124567414
cytogenetic location: 11q24.2

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Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.

This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.