spasticity
Sign in to saveAlso known as Muscle Spasticity
Spasticity () is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles.
Key facts
- Medical condition.name
- Spasticity
- Medical condition.specialty
- Neurology, physical medicine and rehabilitation
via Wikipedia infobox
Research
37,177 papers- Rehabilitation procedures in the management of spasticity.European journal of physical and rehabilitation medicine · 2010
- Spasticity and movement disorders in cerebral palsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
- Clinical Outcome Assessments for Spasticity: Review, Critique, and Recommendations.Movement disorders : official journal of the Movement Disorder Society · 2025
- Spasticity.Handbook of clinical neurology · 2012
- Botulinum Toxin Intervention in Cerebral Palsy-Induced Spasticity Management: Projected and Contradictory Effects on Skeletal Muscles.Toxins · 2022
via PubMed
Clinical Trials
1,279 registered- NAUNKNOWNCan Transcutaneous Electrical Stimulation Garment Improve Gait in Children With Cerebral Palsy?KK Women's and Children's Hospital · NCT04715334
- NACOMPLETEDInfluence of the Spinal Manipulation on Muscle Spasticity and Manual Dexterity in Cerebral Palsy.International Clinic of Rehabilitation, Ukraine · NCT03005938
- NARECRUITINGEffect of Transcranial Direct Current Stimulation on Risk of Falling in Cerebral Palsy Spastic Hemiplegic ChildrenCairo University · NCT06730763
- PHASE3COMPLETEDDose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Leg(s) in Cerebral PalsyMerz Pharmaceuticals GmbH · NCT01893411
- COMPLETEDInteraction Between Spasticity and the Initial Response After Balance Perturbations in Children With Spastic Cerebral PalsyUniversitaire Ziekenhuizen KU Leuven · NCT07616193
- PHASE3COMPLETEDA Study to Evaluate the Efficacy of Sativex in Relieving Symptoms of Spasticity Due to Multiple SclerosisJazz Pharmaceuticals · NCT01599234
Wikidata facts
Show 3 more facts
- exact match
- purl.obolibrary.org/obo/SYMP_0000141
- NCI Thesaurus ID
- C79750
via Wikidata · CC0
~19 min read
Article
13 sectionsContents
- Pathophysiology
- Spasticity and clonus
- Characteristics of spasticity
- Diagnosis
- Grading
- Assessment
- Treatment
- Prognosis
- Research
- History
- See also
- References
- Further reading
Spasticity () is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles.
Clinically, spasticity results from the loss of inhibition of motor neurons, causing excessive velocity-dependent muscle contraction. This ultimately leads to hyperreflexia, an exaggerated deep tendon reflex. Spasticity is often treated with the drug baclofen, which acts as an agonist at GABA receptors, which are inhibitory.