
sphingolipids
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thumb|500px|class=skin-invert|General structures of sphingolipids
Research
52,152 papers- Sphingolipids in metabolic disease: The good, the bad, and the unknown.Cell metabolism · 2021
- Sphingolipids in mitochondria.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017
- Why do we study sphingolipids?Pflugers Archiv : European journal of physiology · 2024
- Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway.Cell host & microbe · 2025
- Functional roles of sphingolipids in immunity and their implication in disease.Experimental & molecular medicine · 2023
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Article
12 sectionsContents
- Structure
- Types
- Mammalian sphingolipid metabolism
- Functions of mammalian sphingolipids
- Other sphingolipids
- Yeast sphingolipids
- Plant sphingolipids
- Disorders
- Additional images
- See also
- References
- External links
thumb|500px|class=skin-invert|General structures of sphingolipids
Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature. These compounds play important roles in signal transduction and cell recognition. Sphingolipidoses, or disorders of sphingolipid metabolism, have particular impact on neural tissue. A sphingolipid with a terminal hydroxyl group is a ceramide. Other common groups bonded to the terminal oxygen atom include phosphocholine, yielding a sphingomyelin, and various sugar monomers or dimers, yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids.