succimer

Also known as DMSA, Chemet, meso-2,3-dimercaptosuccinic acid, meso-dimercaptosuccinic acid

Succimer, sold under the brand name Chemet among others, is a medication tool used to treat lead, mercury, and arsenic poisoning. When radiolabeled with technetium-99m, it is used in many types of diagnostic testing.

Key facts

Drug.legal_US: Rx-only
Drug.H: 6
Drug.O: 4
Drug.CAS_number: 304-55-2
Drug.S: 2
Drug.PubChem: 2724354
Drug.image: Meso-2,3-dimercaptosuccinic-acid-2D-skeletal-A-configurations-labelled.png
Drug.image_class: skin-invert-image
Drug.image2: DMSA-3D-balls.png
Drug.image_class2: bg-transparent
Drug.tradename: Chemet, others
Drug.DailyMedID: Succimer
Drug.ATC_prefix: V03
Drug.ATC_suffix: AB
Drug.DrugBank: DB00566
Drug.ChemSpiderID: 2006502
Drug.UNII: DX1U2629QE
Drug.KEGG: D00572

via Wikipedia infobox

Chemical data

Formula: C4H6O4S2
Molecular weight: 182.2 g/mol
IUPAC name: (2S,3R)-2,3-bis(sulfanyl)butanedioic acid
SMILES: [C@@H]([C@@H](C(=O)O)S)(C(=O)O)S
InChIKey: ACTRVOBWPAIOHC-XIXRPRMCSA-N
XLogP: 0.1
Polar surface area: 76.6 Å²
H-bond donors: 4
H-bond acceptors: 6
Formal charge: 0

via PubChem

Research

2,622 papers

Succimer, an oral lead chelator.Clinical pharmacy · 1991
Succimer: the first approved oral lead chelator.American family physician · 1993
Succimer chelation in a patient with mercury-associated parkinsonism.Clinical toxicology (Philadelphia, Pa.) · 2024
Arsenic Toxicity: Molecular Targets and Therapeutic Agents.Biomolecules · 2020
Succimer chelation does not produce lasting reductions of blood lead levels in a rodent model of retained lead fragments.Environmental toxicology and pharmacology · 2023

via PubMed

Wikidata facts

Mass: 181.970751

Show 5 more facts

chemical formula: C₄H₆O₄S₂
isomeric SMILES: OC(=O)[C@@H](S)[C@@H](S)C(O)=O
Commons category: Dimercaptosuccinic acid
canonical SMILES: C(C(C(=O)O)S)(C(=O)O)S
NCI Thesaurus ID: C61953

Sources (4)

via Wikidata · CC0

~4 min read

Article

6 sections

Contents

Medical uses
Chemistry
Preparation and reactivity
History
References
Further reading

Common side effects include vomiting, diarrhea, rash, and low blood neutrophil levels. Liver problems and allergic reactions may also occur with use. Whether use during pregnancy is safe for the baby is unclear.