TAPBP
Sign in to saveAlso known as NGS17, TAPA, TPN, TPSN, TAP binding protein (tapasin), TAP binding protein
TAP-associated glycoprotein, also known as tapasin or TAPBP, is a protein that in humans is encoded by the TAPBP gene.
Gene data
TAPBP- Name
- TAP binding protein
- Type
- protein-coding
- Aliases
- MHC1D3, NGS17, TAPA, TPN, TPSN
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
TAP binding protein
- Symbol
- TAPBP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_COX_CTG1:4,711,179-4,725,870
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 2401
- exact match
- identifiers.org/ncbigene/6892
- genomic end
- 33314254
- genomic start
- 33267471
- cytogenetic location
- 6p21.32
Sources (3)
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
TAP-associated glycoprotein, also known as tapasin or TAPBP, is a protein that in humans is encoded by the TAPBP gene.
== Function ==