Thioredoxin
Also known as TXN delta 3, testicular tissue protein Li 199, thioredoxin delta 3, TXN, ATL-derived factor, ADF, SASP
Thioredoxin (TRX or TXN) is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the developing embryo. Although not entirely understood, thioredoxin is linked to medicine through their response to reactive oxygen species (ROS). In plants, thioredoxins regulate a spectrum of critical functions, ranging from photosynthesis to growth,
~6 min read
Article
11 sectionsContents
- Occurrence
- Function
- Structure and mechanism
- Interactions
- Effect on cardiac hypertrophy
- Thioredoxin in skin care
- Thioredoxin-Like Proteins
- See also
- References
- Further reading
- External links
Thioredoxin (TRX or TXN) is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the developing embryo. Although not entirely understood, thioredoxin is linked to medicine through their response to reactive oxygen species (ROS). In plants, thioredoxins regulate a spectrum of critical functions, ranging from photosynthesis to growth, flowering and the development and germination of seeds. Thioredoxins play a role in cell-to-cell communication.
==Occurrence== They are found in nearly all known organisms and are essential for life in mammals.