TIMELESS
Sign in to saveAlso known as TIM, TIM1, hTIM, timeless circadian clock, timeless circadian regulator
protein-coding gene in the species Homo sapiens
Gene data
TIMELESS- Name
- timeless circadian regulator
- Type
- protein-coding
- Position
- 56,416,363–56,449,445 (−)
- Aliases
- FASPS4, TIM, TIM1, hTIM
- Ensembl
- ENSG00000111602
- RefSeq RNA
- NM_001330295.2, NM_003920.5, NR_138471.2
- RefSeq protein
- NP_001317224.1, NP_003911.2
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
timeless circadian regulator
- Symbol
- TIMELESS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:56,416,363-56,449,457
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 31206
- exact match
- identifiers.org/ncbigene/8914
- genomic start
- 56416363
- genomic end
- 56449426
- cytogenetic location
- 12q13.3
via Wikidata · CC0