TIPIN

Also known as TIMELESS interacting protein

TIMELESS-interacting protein (TIPIN) is a protein that in humans is encoded by the TIPIN gene.

Gene data

TIPIN

Name: TIMELESS interacting protein
Type: protein-coding

The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].

via MyGene.info

Gene · Ensembl

TIMELESS interacting protein

Symbol: TIPIN
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:66,336,191-66,386,756
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 32373
exact match: identifiers.org/ncbigene/54962
genomic start: 66336191
genomic end: 66679084
cytogenetic location: 15q22.31

Sources (4)

via Wikidata · CC0

~3 min read

Article

6 sections

Contents

Structure
Function
Interactions
Clinical significance
References
Further reading

TIMELESS-interacting protein (TIPIN) is a protein that in humans is encoded by the TIPIN gene.

== Structure == TIPIN is a relatively small protein that lacks known enzymatic activity and functions primarily through protein-protein interactions. It forms a stable complex with TIMELESS, a binding interaction that is essential for its role in the replication stress response. Crystallographic and structural studies have confirmed direct interactions between TIPIN, TIMELESS, and other components of the replication machinery.